(±)-Verapamil hydrochloride; CP-16533-1 hydrochloride MedChemExpress (MCE)

Product Name	Verapamil hydrochloride
Synonyms	CALAN ISOPTIN finoptin IPROVERATRIL Verapamil HCl izoptinhydrochloride Verapamil hydrochloride Synonyms CALAN ISOPTIN finoptin IPROVERATRIL Verapamil HCl izoptinhydrochloride Verapamil hydrochloride iproveratrilhydrochloride benzeneacetonitrile hydrochloride alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-dimethoxyphenyl)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE 5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE 5-[N-(3,4-dimethoxyphenylethyl)METHYLAMINO]-2-(3,4-dimethoxyphenyl)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride
CAS	23313-68-0;152-11-4
EINECS	245-579-2
Chemical Formula	C27H39ClN2O4
Molecular Weight	491.06
inchi	InChI=1/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Verapamil hydrochloride Verapamil hydrochloride MedChemExpress (MCE) HY-A0064 152-11-4 (±)-Verapamil hydrochloride Descriptions Verapamil hydrochloride Verapamil hydrochloride MedChemExpress (MCE) HY-A0064 152-11-4 (±)-Verapamil hydrochloride CP-16533-1 hydrochloride 99.98% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research. The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM[4]. Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation[2]. Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia[5]. Rats[3] Adult male Sprague-Dawley (SD) rats (250−350 g) are used. Verapamil (1 mg/kg) is injected i.v. into a femoral vein 10 min prior to ischemia. A sham group undergoes the same surgical procedures, except the suture underneath the LAD is left untied. In another series of experiment, arrhythmia is induced by Bay K8644, an L-type calcium channel agonist, at a dose of 0.1 mg/kg given i.v. into the FV. Verapamil (1 mg/kg) is administered 10 min prior to Bay K8644. All injections are performed within 30 sec. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 µM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1]. CYP3 \| \| \| \| \| \| \| \| \| \| [1]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr 25(3):743-746. [Content Brief]* [2]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986 21 Suppl 2:183S-189S. [Content Brief] [3]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12 8(8):e71567. [Content Brief] [4]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan 17(1):76-81. [Content Brief] [5]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12 35(5):93. [Content Brief]
Last Update	2025-04-01 14:45:47

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