GNF-5 MedChemExpress (MCE)

Product Name	GNF-5
Synonyms	GNF5 GNF-5 GNF 5 ert-butyl 2-oxopiperidine-1-carboxylate N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5 Synonyms GNF5 GNF-5 GNF 5 ert-butyl 2-oxopiperidine-1-carboxylate N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5 GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
CAS	778277-15-9
EINECS	200-256-5
Chemical Formula	C20H17F3N4O3
Molecular Weight	418.37
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	GNF-5 GNF-5 MedChemExpress (MCE) HY-15738 778277-15-9 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions GNF-5 GNF-5 MedChemExpress (MCE) HY-15738 778277-15-9 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 μM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer. GNF-5 has inhibition of wild-type Abl with an IC50 value of 0.22 μM but no inhibition for myristate site mutant E505K (IC50 ＞10 μM)[1]. GNF-5 (5 mg/kg iv. or 20 mg/kg oral) has suitable pharmacokinetic parameters[1]. GNF-5 (oral, 50 or 100 mg/kg, twice daily, for 7 days) shows efficacious in vivo but can observe relapses[1]. GNF-5 (75 mg/kg, b.i.d) inhibits T315I Bcr-Abl combination with nilotinib in vivo[1]. IC50: 0.22 µM (Abl)[1] In Vitro GNF-5 has inhibition of wild-type Abl with an IC50 value of 0.22 μM but no inhibition for myristate site mutant E505K (IC50 ＞10 μM)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GNF-5 Related Antibodies Cell Viability Assay[1] Cell Line: wild type and mutant Bcr-Abl expressing Ba/F3 cells \| \| \| \| \| \| \| \| \| \| [1]. Zhang J, et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28 463(7280):501-6. [Content Brief] [2]. Meirson T, et al. Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. Oncotarget. 2018 Apr 24 9(31):22158-22183. [Content Brief]
Supplier Website	https://www.medchemexpress.com/GNF-5.html
Last Update	2025-05-21 16:50:25

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