(S)-Duloxetine hydrochloride; LY-248686 hydrochloride MedChemExpress (MCE)

Product Name	(RS)-Duloxetine hydrochloride
Synonyms	Duloxetime Duloxetine HCl Duloxetine hydrochloride (RS)-Duloxetine hydrochloride (rs)-duloxetine hydrochloride N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropana N,N-dimethyl--(1-naphthalenyloxy)-2-Thiophenepropanamine Synonyms Duloxetime Duloxetine HCl Duloxetine hydrochloride (RS)-Duloxetine hydrochloride (rs)-duloxetine hydrochloride N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropana N,N-dimethyl--(1-naphthalenyloxy)-2-Thiophenepropanamine 2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)- (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride (RS)-N-Methyl-gama-(1-phthalenyloxy)-2-thiophenepropamine hydrochloride N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aminium chloride (RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride (rs)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aminium chloride
CAS	116817-11-9;136434-34-9
EINECS	1308068-626-2
Chemical Formula	C19 H21 N O S
Molecular Weight	311.44
inchi	InChI=1/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m1./s1
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Duloxetine hydrochloride Duloxetine hydrochloride MedChemExpress (MCE) HY-B0161A 136434-34-9 (S)-Duloxetine hydrochloride Descriptions Duloxetine hydrochloride Duloxetine hydrochloride MedChemExpress (MCE) HY-B0161A 136434-34-9 (S)-Duloxetine hydrochloride LY-248686 hydrochloride 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine ((S)-Duloxetine hydrochloride) (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia. The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications[1][2]. \| \| \| \| \| \| \| \| \| \| [1]. Redrobe JP, et al. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity. Psychopharmacology (Berl). 1998 Jul 138(1):1-8. [Content Brief]* [2]. Deecher DC, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug 318(2):657-65. Epub 2006 May 4. [Content Brief]
Last Update	2025-04-01 14:45:47

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