Umifenovir hydrochlorideUmifenovir hydrochloride
MedChemExpress (MCE)
HY-14904A
131707-23-8
99.86%
4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year
-20°C, 6 months (sealed storage, away from moisture)
Room temperature in continental US
may vary elsewhere.
Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity.
Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus[1].
Umifenovir (45-180 mg/kg
p.o.
daily for 5 days) suppresses the transcription of influenza viruses (IFV) -associated inflammatory cytokines[2].
Antiviral
Anti-influenza agent Cellular Effect Cell Line Type Value Description References
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[1]. Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008
15(10):997-1005. [Content Brief]
[2]. Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013
34(8):1075-1083. [Content Brief]
[3]. Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020
6:28. Published 2020 May 2. [Content Brief]