AGN 192024 MedChemExpress (MCE)

Product Name	Bimatoprost
Synonyms	LUMIGAN BIMATOPROST Bimatoprost Bimatoprost(TM) BIMATOPROST(TM) BIMATOPROST(LUMIGAN) Bimatoprost(LUMIGAN) Synonyms LUMIGAN BIMATOPROST Bimatoprost Bimatoprost(TM) BIMATOPROST(TM) BIMATOPROST(LUMIGAN) Bimatoprost(LUMIGAN) 17-phenyl-tri-norprostaglandin f2α-ethyl amide 17-phenyl TRINOR prostaglandin F2ALPHA ethyl amide 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE N-ethyl-9ALPHA,11ALPHA,15S-Trihydroxy-17-phenyl-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-amide (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide (5E)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
CAS	155206-00-1
EINECS	642-890-9
Chemical Formula	C25H37NO4
Molecular Weight	415.57
inchi	InChI=1/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3+,17-16+/t20-,21+,22+,23-,24+/m0/s1
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Bimatoprost Bimatoprost MedChemExpress (MCE) HY-B0191 155206-00-1 AGN 192024 99.93% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Bimatoprost Bimatoprost MedChemExpress (MCE) HY-B0191 155206-00-1 AGN 192024 99.93% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus. Bimatoprost (10-1000 μM 24 h) dose-dependently upregulates the mRNA levels of cellular matrix metalloproteinases MMP1 and MMP14 in human trabecular meshwork (TM), iris fibroblasts (SF), and ciliary muscle (CM) cells[4]. Bimatoprost (0.3 μg/μL topical application single dose injection of 4 μL) is dependent on FP receptor expression in the eyes of C57BL/6 mice in the early IOP response[6]. \| \| \| \| \| \| \| \| \| \| [1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan 55(1):22-7. [Content Brief] [2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug 24(4):302-7. [Content Brief] [3]. Stamer W D, et al. Proposed mechanism of long-term intraocular pressure lowering with the bimatoprost implant[J]. Investigative Ophthalmology & Visual Science, 2023, 64(3): 15-15. [Content Brief] [4]. Patil A J, et al. Bimatoprost–a review[J]. Expert opinion on pharmacotherapy, 2009, 10(16): 2759-2768. [Content Brief] [5]. Woodward, et al. "Bimatoprost: a novel antiglaucoma agent." Cardiovascular drug reviews 22.2 (2004): 103-120. [Content Brief] [6]. Crowston, et al. "Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice." Investigative ophthalmology & visual science 46.12 (2005): 4571-4577. [Content Brief]
Last Update	2025-04-01 14:45:47

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