F-ara-A; NSC 118218 MedChemExpress (MCE)

Product Name	Fludarabine
Synonyms	f-ara-a NSC 118218 Fludarabine NSC 118218H Fludarabine base Fludarabine(base) 2-Fluoroadeninearabinoside Synonyms f-ara-a NSC 118218 Fludarabine NSC 118218H Fludarabine base Fludarabine(base) 2-Fluoroadeninearabinoside 9-beta-D-Arabinofuranosyl-2-fluoroadenine 9-bata-D-Arabinofuranosyl-2-fluoroadenine 9-beta-d-arabinofuranosyl-2-fluoro-adenin 2-Fluoroadenine-9-bata-D-arabinofuranoside 6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE 9--D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine 9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin 9-(beta-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine
CAS	21679-14-1
EINECS	244-525-5
Chemical Formula	C10H12FN5O4
Molecular Weight	285.23
inchi	InChI=1/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Fludarabine Fludarabine MedChemExpress (MCE) HY-B0069 21679-14-1 F-ara-A Descriptions Fludarabine Fludarabine MedChemExpress (MCE) HY-B0069 21679-14-1 F-ara-A NSC 118218 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. Fludarabine (5 μM 48?hours) induces a decrease in p27kip1 expression[4]. Fludarabine (0.8 mg/kg i.p. two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg i.p. 2 weeks) decreases incidence of GVHD[6]. \| \| \| \| \| \| \| \| \| \| [1]. Liang YB, et al. Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type. Mol Med Rep. 2017 Nov 16(5):6405-6411. [Content Brief] [2]. Sanhes L, et al. Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases. Leukemia. 2003 Jun 17(6):1104-11. [Content Brief] [3]. Frank DA, et al. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999 5(4):444-447. [Content Brief] [4]. Frank DA,et al. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999 Apr 5(4):444-7. [Content Brief] [5]. Tournilhac O, et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1 103(1):363-5. Epub 2003 Sep 11. [Content Brief] [6]. Weiss L, et al. Fludarabine in combination with cyclophosphamide decreases incidence of GVHD and maintainseffective graft-versus-leukemia effect after allogeneic stem cell transplantation in murinelymphocytic leukemia. Bone Marrow Transplant. 2003 Jan 31(1):11-5. [Content Brief]
Supplier Website	https://www.medchemexpress.com/fludarabine.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact