Cefaclor MedChemExpress (MCE)

Product Name	cefaclor
Synonyms	Kefral S 6472 Alfacet Panoral Raniclor cefaclor CEFACLOR Synonyms Kefral S 6472 Alfacet Panoral Raniclor cefaclor CEFACLOR Ceclor CD Cephaclor Cefaclorum Lilly 99638 UNII-3Z6FS3IK0K Cefaclor anhydrous 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid 7-(D-2-AMINO-2-PHENYLACETAMIDO)-3-CHLORO-3-CEPHEM-4-CARBOXYLIC ACID 8-(2-AMINO-2-PHENYL-ACETYL)AMINO-4-CHLORO-7-OXO-2-THIA-6-AZABICYCLO[4.2.0]OCT-4-ENE-5-CARBOXYLIC ACID (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, (6R,7R)- (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, [6R-[6α,7β(R)]]- (6R,7R)-7-[[(2S)-2-amino-1-oxo-2-phenylethyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6S,7R)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3-chloro-6-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6-alpha,7-beta(R)))-
CAS	53994-73-3
EINECS	258-909-5
Chemical Formula	C15H14ClN3O4S
Molecular Weight	367.81
inchi	InChI=1/C16H16ClN3O4S/c1-16-12(19-13(21)10(18)8-5-3-2-4-6-8)14(22)20(16)11(15(23)24)9(17)7-25-16/h2-6,10,12H,7,18H2,1H3,(H,19,21)(H,23,24)/t10-,12-,16+/m1/s1
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Cefaclor Cefaclor MedChemExpress (MCE) HY-B0198 53994-73-3 99.61% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Cefaclor Cefaclor MedChemExpress (MCE) HY-B0198 53994-73-3 99.61% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections. Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro[4]. Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1、hPepT1 and hPepT2[2]. Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells[3]. Cefaclor (200 mg/kg/day, p.o. once a day for 5 days) can cause intestinal flora imbalance in mice, as well as anxiety and depression-like behaviors in mice. These symptoms can be alleviated by Fluoxetine (HY-B0102) or vagotomy[1]. β-lactam hOAT1 hPepT1-人肽转运蛋白 1 hPepT2-人肽转运蛋白 2 CD63 BDNF 5-HT Receptor \| \| \| \| \| \| \| \| \| \| [1]. Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19 13(1):15529. [Content Brief] [2]. Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr 34(4):547-55. [Content Brief] [3]. Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov 55(6):1473-83. [Content Brief] [4]. Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr 13(4):584-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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