R 065824 MedChemExpress (MCE)

Product Name	Nebivolol
Synonyms	R-65824 Nebivolol Nibivolol NEBIVOLOL-D4 rac-Nebivolol (Mixture of Diastereomers) 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol) Nebivolol Impurity 6(rac-Nebivolol (Mixture of Diastereomers)) Synonyms R-65824 Nebivolol Nibivolol NEBIVOLOL-D4 rac-Nebivolol (Mixture of Diastereomers) 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol) Nebivolol Impurity 6(rac-Nebivolol (Mixture of Diastereomers)) 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-methanol) 2H-1-Benzopyran-2-methanol, alpha,alpha'- (iminobis(methylene))bis(6-fluoro-3,4-dihydro- [2R[R[R(S)]]]-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol
CAS	99200-09-6;118457-14-0
EINECS
Chemical Formula	C22H25F2NO4
Molecular Weight	405.43
inchi	InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
Package	5 mg;10 mg
Price	Email to quote
Descriptions	Nebivolol Nebivolol MedChemExpress (MCE) HY-B0203 118457-14-0 R 065824 99.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Nebivolol Nebivolol MedChemExpress (MCE) HY-B0203 118457-14-0 R 065824 99.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease. Nebivolol improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties[1]. Nebivolol (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM[2]. Nebivolol (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis[2]. Nebivolol (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs[2] \| \| \| \| \| \| \| \| \| \| [1]. Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13 54(16):1491-9. [Content Brief] [2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1 49(2):430-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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