OPC-34712 MedChemExpress (MCE)

Product Name	Brexpiprazole
Synonyms	CS-1678 OPC34712 OPC 34712 OPC34712 OPC-34712 OPC-34712 Brexpiprazole Synonyms CS-1678 OPC34712 OPC 34712 OPC34712 OPC-34712 OPC-34712 Brexpiprazole Brexpiprazoleimpuritya Brexpiprazole(OPC34712) Brexpiprazole impurity a 7-{4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one 7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one
CAS	913611-97-9
EINECS	811-628-7
Chemical Formula	C25H27N3O2S
Molecular Weight	433.57
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Brexpiprazole Brexpiprazole MedChemExpress (MCE) HY-15780 913611-97-9 OPC-34712 99.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Brexpiprazole Brexpiprazole MedChemExpress (MCE) HY-15780 913611-97-9 OPC-34712 99.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). Brexpiprazole (0-1.0 μM, 4 days) potentiates NGF-induced neurite outgrowth in a dose-dependent manner in PC12 cells[1]. Brexpiprazole (0-0.1 mg/kg p.o. once) improves social recognition deficits in mice[2]. 5-HT1A Receptor 0.12 nM (Ki) 5-HT2A Receptor 0.47 nM (Ki) D2L Receptor 0.3 nM (Ki) human noradrenergic α1B 0.17 nM (Ki) human noradrenergic α2C 0.59 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr 25(4):505-11. [Content Brief] [2]. Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar 25(3):356-64. [Content Brief]
Last Update	2025-04-01 14:45:47

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