Phenazone; Phenazon MedChemExpress (MCE)

Product Name	Antipyrine
Synonyms	Phenylon Phenozone Phenylone Antipyrin APYRETINE Phenazone Antipyrine Synonyms Phenylon Phenozone Phenylone Antipyrin APYRETINE Phenazone Antipyrine Pyrazophyl Antipyrene Antypirine antipyrin(R) phenazone(pharmaceutical) Phenyldimethyl isopropyl pyrazolone 1,5-Dimethyl1-2-phenyl-3-pyrazolone Antipyrine,(2,3-Dimethyl-1-phenyl-3-pyr 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one 1,5-dimethyl-2-phenyl-pyrazolidin-3-one 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-one
CAS	60-80-0
EINECS	200-486-6
Chemical Formula	C11H12N2O
Molecular Weight	188.23
inchi	InChI: 1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
Package	10 mM * 1 mL;500 mg
Price	Email to quote
Descriptions	Antipyrine Antipyrine MedChemExpress (MCE) HY-B0171 60-80-0 Phenazone Descriptions Antipyrine Antipyrine MedChemExpress (MCE) HY-B0171 60-80-0 Phenazone Phenazon 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats. Antipyrine (0.1-100 mM, 15 min) metabolites are formed by at least six hepatic cytochrome P450 enzymes (CYPlA2, CYP2B6, CYP2C8, CYP2C9, CYP2C18, and CYP3A4) in human liver microsomes[3]. Antipyrine (45.17 mg/kg, i.v., 10 minutes before the evaluation of gastric retention) delays gastric emptying (GE) of liquid in rats with the participation of the vagus nerve, which is blocked by the activation of GABAB receptors in the central nervous system[4]. \| \| \| \| \| \| \| \| \| \| [1]. Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4(3): p. 261-5. [Content Brief] [2]. Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun 59(6):613-23. [Content Brief] [3]. RENKIN EM. Capillary and cellular permeability to some compounds related to antipyrine. Am J Physiol. 1953 Apr 173(1):125-30. [Content Brief] [4]. Soares AC, et al. Effect of antipyrine on the gastric emptying of liquid in rats. Braz J Med Biol Res. 2006 Nov 39(11):1507-12. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Antipyrine.html
Last Update	2025-04-01 14:45:47

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