DM-235 MedChemExpress (MCE)

Product Name	Piperazine,1-benzoyl-4-(1-oxopropyl)-
Synonyms	DM235 DM 235 DM-235 SunifiraM Sunifiram DM235 1-Benzoyl-4-propanoylpiperazine 1-Benzoyl-4-(1-oxopropyl)-piperazine Synonyms DM235 DM 235 DM-235 SunifiraM Sunifiram DM235 1-Benzoyl-4-propanoylpiperazine 1-Benzoyl-4-(1-oxopropyl)-piperazine Piperazine,1-benzoyl-4-(1-oxopropyl)- 1-(4-Benzoylpiperazin-1-yl)propan-1-one 1-(4-Benzoyl-1-piperazinyl)-1-propanone
CAS	314728-85-3
EINECS	1312995-182-4
Chemical Formula	C14H18N2O2
Molecular Weight	246.3
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Sunifiram Sunifiram MedChemExpress (MCE) HY-17550 314728-85-3 DM-235 99.89% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions Sunifiram Sunifiram MedChemExpress (MCE) HY-17550 314728-85-3 DM-235 99.89% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD). Sunifiram (0.01-1 μM, 30 minutes) reduced the antagonistic effect of kynurenic acid on NMDA and increased NMDA activity[4]. Sunifiram (0.001-0.1 mg/kg, p.o. or i.v., single dose, 20 minutes prior) is able to prevent amnesia in a scopolamine (HY-N0296)-induced amnesia mouse model[4]. \| \| \| \| \| \| \| \| \| \| [1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec 368(6):538-45. [Content Brief] [2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3. [Content Brief] [3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1 242:150-7. [Content Brief] [4]. Romanelli M N, et al. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers[J]. CNS Drug Reviews, 2006, 12(1): 39-52. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Sunifiram.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact