GlyH-101 MedChemExpress (MCE)

Product Name	N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
Synonyms	GLYH 101 GLYH-101 GlyH-101 CFTR Inhibitor II, GlyH-101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide Synonyms GLYH 101 GLYH-101 GlyH-101 CFTR Inhibitor II, GlyH-101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II
CAS	328541-79-3
EINECS
Chemical Formula	C19H15Br2N3O3
Molecular Weight	493.15
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	GlyH-101 GlyH-101 MedChemExpress (MCE) HY-18336 328541-79-3 99.68% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions GlyH-101 GlyH-101 MedChemExpress (MCE) HY-18336 328541-79-3 99.68% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current. GlyH-101 (0-50 μM) shows antiproliferative activity in PCT and PS120 cells[1]. GlyH-101 (0.5, 1, 5, 10 μM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells[1]. GlyH-101 (0.5, 1, 5, 10 μM) inhibits the VSORC current with IC50s of 5.38, 6.26 μM for PS120, PCT cells, respectively[1]. GlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse[2]. \| \| \| \| \| \| \| \| \| \| [1]. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug 124(2):125-37. [Content Brief] [2]. Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr 333(1):60-9. [Content Brief] [3]. Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29 408(1):12-7. [Content Brief] [4]. Melis N, et al. Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. Br J Pharmacol. 2014 Aug 171(15):3716-27. [Content Brief] [5]. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug 124(2):125-37. [Content Brief]
Last Update	2025-04-01 14:45:47

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