Rifampin; Rifamycin AMP MedChemExpress (MCE)

Product Name	rifampicin
Synonyms	RIF Rifa Eremfat Rifobac Rifadin Riforal Rimycin Synonyms RIF Rifa Eremfat Rifobac Rifadin Riforal Rimycin Dipicin Rifater Abrifam Rifandin Rimactan Rifoldin Rifamate Rifampin Rifaldin rifampicin Rifaprodin rifaldazine Rifadin I.V. Rifamicin AMP Rifamycin SV Sodium RIFAMPIN ''LEPETIT'' 8-(4-Methylpiperazinyliminomethyl)rifamycinSV 3-((4-methyl-1-piperazinyl)iminomethyl)rifamycinsv 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins 3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci 3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin 8-(((4-methyl-1-piperazinyl)imino)methyl)rifamycinsv 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2-h)-dione,5,6 (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
CAS	13292-46-1
EINECS	236-312-0
Chemical Formula	C43H58N4O12
Molecular Weight	822.94
inchi	InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20?/t21?,23-,24-,25-,29+,34+,35-,39+,43+/m1/s1
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Rifampicin Rifampicin MedChemExpress (MCE) HY-B0272 13292-46-1 Rifampin Descriptions Rifampicin Rifampicin MedChemExpress (MCE) HY-B0272 13292-46-1 Rifampin Rifamycin AMP 98.15% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity. Rifampicin (100 microg/mL) can block the functional activity of P-glycoprotein. Rifampicin is not a substract for P-glycoprotein. The mechanism of rifampicin resistance is unassociated with the functional activity of P-glycoprotein[3]. Rifampicin (200, 400 mg/kg) can induce fatty liver at high concentration[1]. Rifampicin (30 mg/kg, i.p.) treatment of S464P biofilms in vivo results in a slight decline, but earlier rebinds in bioluminescence from these catheters compared with the parental signal, whereas rifampicin has no affect on bioluminescence in mice infected with mutant H481Y[2]. Briefly, 1 cm Teflon catheter (14-gauge) carrying 104 cfu S. aureus, either the parental strain Xen 29 or the RifR mutants S464P or H481Y, are implanted subcutaneously in groups of nine mice per strain. One catheter segment is inserted on each side of each animal. Six days after the implantation of the catheters, five mice from each group are treated with rifampicin at 30 mg/kg intraperitoneally in 0.1 mL saline, twice daily for four consecutive days. The remaining four mice in each group are left untreated as controls. At various time points during the infection, the mice are anaesthetized using a constant flow of 1.5% isoflurane from the IVIS® manifold, and imaged using an IVIS® Image System 100 Series. The bioluminescent signals (photons/s) emitted from the mice are analysed using LivingImage® software and plotted over the course of infection. The mice are sacrificed 20 days after infection (11 days after final rifampicin treatment). The catheters are surgically removed and the bacteria are detached by sonication for determination of bacterial burdens on the catheters. \| \| \| \| \| \| \| \| \| \| [1]. Piriou A, et al. Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerases in eukariotic cells. Arch Toxicol Suppl. 1979 (2):333-7. [Content Brief] [2]. Yu J, et al. Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model. J Antimicrob Chemother. 2005 Apr 55(4):528-34. Epub 2005 Mar 2. [Content Brief] [3]. Erokhina MV, et al. [In vitro development of rifampicin resistance in the epithelial cells]. Probl Tuberk Bolezn Legk. 2006 (8):58-61. [Content Brief] [4]. Hamzehei M, et al. Inhibition of influenza A virus replication by rifampicin and selenocystamine. J Med Virol. 1980 6(2):169-74. [Content Brief] [5]. Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan 57(1-2):41-52. [Content Brief]
Supplier Website	https://www.medchemexpress.com/rifampicin.html
Last Update	2025-05-21 16:50:25

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