PLpro inhibitor MedChemExpress (MCE)

Product Name	PLpro inhibitor
Synonyms	BENZAMIDE PLpro inhibitor 5-acetamido-2-methyl-n-(2-naphthalen-1-ylethyl)benzamide 5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]- Synonyms BENZAMIDE PLpro inhibitor 5-acetamido-2-methyl-n-(2-naphthalen-1-ylethyl)benzamide 5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]- 5-(ACETYLAMINO)-2-METHYL-N-[(1R)-1-(1-NAPHTHALENYL)ETHYL]- 5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide 5-Acetylamino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide 5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
CAS	1093070-14-4
EINECS
Chemical Formula	C22H22N2O2
Molecular Weight	346.42
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	PLpro inhibitor PLpro inhibitor MedChemExpress (MCE) HY-17542 1093070-14-4 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions PLpro inhibitor PLpro inhibitor MedChemExpress (MCE) HY-17542 1093070-14-4 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM. PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells[1][3]. IC50 : 2.6 µM (Papain-like protease (PLpro))[1] 5.0 µM (SARS-CoV-2 PLpro)[2] EC50: 21.0 µM (SARS-CoV-2 PLpro)[2] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24. [Content Brief] [2]. http://www.google.com/patents/WO2010022355A1cl=en [3]. Brendan T Freitas, et al. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS Infect Dis. 2020 May 19. [Content Brief]
Last Update	2025-04-01 14:45:47

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