HS-592 fumarate; Meclastine fumarate MedChemExpress (MCE)

Product Name	clemastine fumarate
Synonyms	CLEMASTINE CLEMASTINUM CLEMASTINE FUMARATE clemastine fumarate CLEMASTINE FUMARATE SALT clemastine hydrogen fumarate 2-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine Synonyms CLEMASTINE CLEMASTINUM CLEMASTINE FUMARATE clemastine fumarate CLEMASTINE FUMARATE SALT clemastine hydrogen fumarate 2-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)- (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R,R)]- [2R,(+)]-2-[2-[[(R)-1-(p-Chlorophenyl)-1-phenylethyl]oxy]ethyl]-1-methylpyrrolidine Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI) (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2E)-but-2-enedioate
CAS	14976-57-9;15686-51-8
EINECS	239-055-2
Chemical Formula	C21H26ClNO
Molecular Weight	343.89
inchi	InChI=1/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
Package	10 mM * 1 mL;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Clemastine fumarate Clemastine fumarate MedChemExpress (MCE) HY-B0298A 14976-57-9 HS-592 fumarate Descriptions Clemastine fumarate Clemastine fumarate MedChemExpress (MCE) HY-B0298A 14976-57-9 HS-592 fumarate Meclastine fumarate 99.97% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects. Clemastine (fumarate) (HS-592 (fumarate)) inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM as compared with that of chlorpheniramine or diphenhydramine with IC50 values of 20 nM and 100 nM, respectively[1]. Clemastine showed a first-pass reduction in the extent of absorption, with oral bioavailability calculated as 39.2 +/- 12.4%. Extravascular distribution of drug was suggested by the high volume of distribution (799 +/- 315 L) and low Cmax (0.577 +/- 0.252 ng/mL/mg) observed at 4.77 +/- 2.26 hours after administration, and by the biphasic decline in plasma concentration. The terminal elimination half-life (t1/2) of clemastine was 21.3 +/- 11.6 hours. Steady-state concentrations of clemastine were consistent with linear pharmacokinetic processes, and clearance was unaffected by age in the range studied, or by race[2]. H1 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34. [Content Brief]* [2]. Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases January 16, 2017. [Content Brief]
Last Update	2025-04-01 14:45:47

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