INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide MedChemExpress (MCE)

Product Name	Isonicotinic acid hydrazide
Synonyms	INAH Isoniazid Isoniazide isonicotinohydrazide ISONICOTINYLHYDRAZIDE Isonicotinic hydrazide Pyridine-4-carbohydrazide Synonyms INAH Isoniazid Isoniazide isonicotinohydrazide ISONICOTINYLHYDRAZIDE Isonicotinic hydrazide Pyridine-4-carbohydrazide pyridine-3-carbohydrazide 4-(hydrazinomethyl)pyridine Isonicotinic acid hydrazide Pyridine-4-carboxylic hydrazide
CAS	54-85-3
EINECS	200-214-6
Chemical Formula	C6H7N3O
Molecular Weight	137.14
inchi	InChI=1/C6H7N3O2/c7-9-11-6(10)5-1-3-8-4-2-5/h1-4,9H,7H2
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Isoniazid Isoniazid MedChemExpress (MCE) HY-B0329 54-85-3 INH Descriptions Isoniazid Isoniazid MedChemExpress (MCE) HY-B0329 54-85-3 INH Isonicotinic acid hydrazide Isonicotinic hydrazide 99.91% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. Isoniazid (INH) is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG[1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824[2][3]. Isoniazid is bactericidal to rapidly dividing mycobacteria but is bacteriostatic if the mycobacteria are slow-growing[4]. \| \| \| \| \| \| \| \| \| \| [1]. Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). J Biol Chem, 2009. 284(11): p. 7017-29. [Content Brief]* [2]. Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48(8): p. 3006-9. [Content Brief] [3]. Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322(5906): p. 1392-5. [Content Brief] [4]. Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200(7): p. 1136-43. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Isoniazid.html
Last Update	2025-05-21 16:50:25

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