(+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride MedChemExpress (MCE)

Product Name	dexmedetomidine HCL
Synonyms	DEMEDETOMIDINE HCL demedetomidine HCL DEXMEDETOMIDINE HCL dexmedetomidine HCL Dexmedetomidine(Pilot) Dexmedetomidine Hydrochloride DEXMEDETOMIDINE HYDROCHLORIDE Synonyms DEMEDETOMIDINE HCL demedetomidine HCL DEXMEDETOMIDINE HCL dexmedetomidine HCL Dexmedetomidine(Pilot) Dexmedetomidine Hydrochloride DEXMEDETOMIDINE HYDROCHLORIDE dexmedetomidine hydrochloride 4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride 4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride 4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride
CAS	145108-58-3
EINECS	682-047-2
Chemical Formula	C13H17ClN2
Molecular Weight	236.74
inchi	InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Dexmedetomidine hydrochloride Dexmedetomidine hydrochloride MedChemExpress (MCE) HY-17034A 145108-58-3 (+)-Medetomidine hydrochloride Descriptions Dexmedetomidine hydrochloride Dexmedetomidine hydrochloride MedChemExpress (MCE) HY-17034A 145108-58-3 (+)-Medetomidine hydrochloride (S)-Medetomidine hydrochloride 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects. Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine[1]. Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0[1]. Medetomidine (10-100 μg/kg i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats[1]. α2-adrenergic receptor 1.08 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20 150(1-2):9-14. [Content Brief]* [2]. Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001 Jan 14(1):13-21. [Content Brief] [3]. Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019 35(1):36-40. [Content Brief]
Last Update	2025-04-01 14:45:47

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