(R)-AGN1135 mesylate; TVP1012 mesylate MedChemExpress (MCE)

Product Name	Rasagiline mesylate
Synonyms	CS-289 Agilect Rasagiline mesylate R-(+)-Rasagiline mesylate (R)-N-2-Propynyl-1-indanamine Mesylate (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine Mesylate (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate Synonyms CS-289 Agilect Rasagiline mesylate R-(+)-Rasagiline mesylate (R)-N-2-Propynyl-1-indanamine Mesylate (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine Mesylate (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-inden-1-amine methanesulfonate
CAS	161735-79-1
EINECS	694-423-3
Chemical Formula	C13H17NO3S
Molecular Weight	267.34398
inchi	InChI=1/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Rasagiline mesylate Rasagiline mesylate MedChemExpress (MCE) HY-14605 161735-79-1 (R)-AGN1135 mesylate Descriptions Rasagiline mesylate Rasagiline mesylate MedChemExpress (MCE) HY-14605 161735-79-1 (R)-AGN1135 mesylate TVP1012 mesylate 99.82% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Rasagiline (0.25 nM 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 μM) treatment[2]. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy[3]. rMAO-B 4.43 nM (IC50) rMAO-A 412 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. M B Youdim, et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan 132(2):500-6. [Content Brief]* [2]. Shawna Tazik, et al. Comparative neuroprotective effects of Rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis. Neurotox Res. 2009 Apr 15(3):284-90. [Content Brief] [3]. Nadia Stefanova, et al. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Exp Neurol. 2008 Apr 210(2):421-7. [Content Brief]
Last Update	2025-04-01 14:45:47

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