BTB06584 MedChemExpress (MCE)

Product Name	BTB06584
Synonyms	CS-1880 BTB06584 BTB-06584 BTB 06584 AHAS inhibitor -Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester Synonyms CS-1880 BTB06584 BTB-06584 BTB 06584 AHAS inhibitor -Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester AHAS inhibitor BTB06584 AHAS inhibitor 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
CAS	219793-45-0
EINECS
Chemical Formula	C19H12ClNO6S
Molecular Weight	417.82
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	BTB06584 BTB06584 MedChemExpress (MCE) HY-15877 219793-45-0 99.60% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions BTB06584 BTB06584 MedChemExpress (MCE) HY-15877 219793-45-0 99.60% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death. In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced[1]. BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein[1]. BTB06584 (1 μM 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish[1]. Mitochondrial F1Fo-ATPase[1] In Vitro In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced[1]. BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BTB06584 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Ivanes F, et al. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014 Sep 171(18):4193-4206. [Content Brief]
Last Update	2025-04-01 14:45:47

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