Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride MedChemExpress (MCE)

Product Name	clomipramine hydrochloride
Synonyms	Clomipramine HCl CLOMIPRAMINE HCL Chloroimipram-ine HCl CLOMIPRAMINE HYDROCHLORIDE clomipramine hydrochloride CHLORIMIPRAMINE HYDROCHLORIDE CHLOROIMIPRAMINE HYDROCHLORIDE Synonyms Clomipramine HCl CLOMIPRAMINE HCL Chloroimipram-ine HCl CLOMIPRAMINE HYDROCHLORIDE clomipramine hydrochloride CHLORIMIPRAMINE HYDROCHLORIDE CHLOROIMIPRAMINE HYDROCHLORIDE 3-chloroimipraminehydrochloride 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(b,f)azepinemono 3-CHLORO-10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine monohydrochloride
CAS	17321-77-6
EINECS	241-344-3
Chemical Formula	C19H24Cl2N2
Molecular Weight	351.31
inchi	InChI=1/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
Package	10 mM * 1 mL;100 mg;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Clomipramine hydrochloride Clomipramine hydrochloride MedChemExpress (MCE) HY-B0457 17321-77-6 Chlorimipramine hydrochloride Descriptions Clomipramine hydrochloride Clomipramine hydrochloride MedChemExpress (MCE) HY-B0457 17321-77-6 Chlorimipramine hydrochloride G-34586 hydrochloride NSC-169865 hydrochloride 99.14% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD). Clomipramine hydrochloride can inhibit reuptake of both noradrenaline and 5-HT, although Clomipramine inhibits 5-HT reuptake more strongly than it inhibits noradrenaline reuptake[1]. The antidepressant Clomipramine inhibits both venom AChE as well as human serum BChE in a concentration-dependent manner but has no effect on AChE in the rat brain striatum[2]. Clomipramine hydrochloride interferes with the autophagic flux and severely compromises the viability of tumorigenic cells upon cytotoxic stress[3]. Clomipramine hydrochloride reduces autophagy in neuronal primary cultures. Clomipramine (1 and 5 μM) hydrochloride negatively regulates neuronal autophagic pathway in primary cultured cells[3]. Clomipramine (5-20 mg/kg i.p) hydrochloride elicits significant hyperglycemia in mice. Clomipramine hydrochloride induces hyperglycemia in mice by blocking the 5-HT2B and/or 5-HT2C receptors, which results in facilitation of adrenaline release. In mice, Clomipramine hydrochloride reduces immobility in the forced swimming test, which is the behavioral model for antidepressants. Clomipramine hydrochloride also inhibits the OCD animal model, marble burying behavior in mice[1].Clomipramine (20 mg/kg) hydrochloride decreases autophagic flux in murine tissues[3]. \| \| \| \| \| \| \| \| \| \| [1]. Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep 93(1):74-9. [Content Brief]* [2]. Mushtaq Ahmed, et al. Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum. J Enzyme Inhib Med Chem. 2008 Dec 23(6):912-7. [Content Brief] [3]. Federica Cavaliere,The tricyclic antidepressant Clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19 9(1):4881. [Content Brief]
Last Update	2025-04-01 14:45:47

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