MPV785 MedChemExpress (MCE)

Product Name	Medetomidine hydrochloride
Synonyms	Domitor MPV 785 Zalopine Metomidine MEDETOMIDINE HCL medetomidine HCL Medetomidine hydrochloride Synonyms Domitor MPV 785 Zalopine Metomidine MEDETOMIDINE HCL medetomidine HCL Medetomidine hydrochloride 4-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1H-IMIDAZOLE HYDROCHLORIDE 4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride (r)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride 1H-Imidazole, 4-1-(2,3-dimethylphenyl)ethyl-, monohydrochloride
CAS	106807-72-1;86347-15-1
EINECS	1308068-626-2
Chemical Formula	C13H17ClN2
Molecular Weight	236.74
inchi	InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Medetomidine hydrochloride Medetomidine hydrochloride MedChemExpress (MCE) HY-17034B 86347-15-1 MPV785 99.80% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Medetomidine hydrochloride Medetomidine hydrochloride MedChemExpress (MCE) HY-17034B 86347-15-1 MPV785 99.80% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels. Medetomidine (0-1 μM, 1 h) hydrochloride inhibits aldosterone release from the adrenocortical cell suspension[7]. Medetomidine (10 nM) hydrochloride activates a kicking response in Cyprids[8]. Medetomidine (1 μM) hydrochloride increases cellular cAMP production by activating β-like receptors in CHO cells[8]. Medetomidine (200 μg/kg, p.o. or i.m.) hydrochloride induces a sedation in cats[4]. Medetomidine (20 μg/kg, i.v.) hydrochloride shows sedative and analgesic effects in dogs[5]. Medetomidine (0.05-0.3 mg/kg, s.c.) hydrochloride protects against Diazinon-induced toxicosis in mice[6]. α2-adrenergic receptor 1.08 nM (Ki) α1-adrenergic receptor 1750 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Kallio A, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep 119(1):11-5. [Content Brief] [3]. R Virtanen, et al. Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. [Content Brief] [4]. O. B. Ansah, et al. Comparing oral and intramuscular administration of medetomidine in cats. [5]. Kuo WC, et al. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul 65(7):931-7. [Content Brief] [6]. Yakoub LK, et al. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19 93(1):1-8. [Content Brief] [7]. Jager LP, et al. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3 346(1):71-6. [Content Brief] [8]. Ulrika Lind, et al. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. [Content Brief]
Last Update	2025-04-01 14:45:47

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