GBR-12909 dihydrochloride; I893 dihydrochloride MedChemExpress (MCE)

Product Name	Vanoxerine dihydrochloride
Synonyms	I-893 I 893 Gbr-12909 Gbr 12909 GBR 12909 I893 dihydrochloride Vanoxerine hydrochloride Synonyms I-893 I 893 Gbr-12909 Gbr 12909 GBR 12909 I893 dihydrochloride Vanoxerine hydrochloride GBR 12909 DIHYDROCHLORIDE gbr-12909 dihydrochloride Vanoxerine dihydrochloride GBR-12909 DIHYDROCHLORIDE SELECTIVE DOPA MINE UP 1-(2 (Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine di-hcl 1-(2-BIS-((4-FLUOROPHENYL)METHOXY)ETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HCL 1-(2-[BIS(4-FLUOROPHENYL) METHOXY]ETHYL)-4-(3-PHENYLPROPYL) PIPERAZINE DIHYDROC 1-[2-[BIS(4-FLUOROPHENYL)METHOXY]ETHYL]-4-[3-PHENYLPROPYL]PIPERAZINE DIHYDROCHLORIDE 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride 1-(2-BIS-[4-FLUOROPHENYL]-METHOXYETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HYDROCHLORIDE Piperazine, 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)-, dihydrochloride
CAS	67469-78-7
EINECS
Chemical Formula	C28H33ClF2N2O
Molecular Weight	487.03
inchi	InChI=1/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Vanoxerine dihydrochloride Vanoxerine dihydrochloride MedChemExpress (MCE) HY-13217 67469-78-7 GBR-12909 dihydrochloride Descriptions Vanoxerine dihydrochloride Vanoxerine dihydrochloride MedChemExpress (MCE) HY-13217 67469-78-7 GBR-12909 dihydrochloride I893 dihydrochloride 99.60% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2]. Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3]. Vanoxerine dihydrochloride (2.5-20 mg/kg i.p.) significantly increases the ambulatory activity[3]. Ki: 1 nM (dopamine reuptake)[1] In Vitro Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2]. Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Vanoxerine dihydrochloride Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Rothman RB, et al. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochem Pharmacol. 2008 Jan 1 75(1):2-16. [Content Brief]* [2]. Hirate K, et al. Characteristics of the ambulation-increasing effect of GBR-12909, a selective dopamine uptakeinhibitor, in mice. Jpn J Pharmacol. 1991 Apr 55(4):501-11. [Content Brief] [3]. Andersen PH. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact