Octylonium bromide; SP63 MedChemExpress (MCE)

Product Name	Otilonium bromide
Synonyms	SP-63 Spasen Menoctyl Pasminox Spasmome Otilonium 247-457-4 Synonyms SP-63 Spasen Menoctyl Pasminox Spasmome Otilonium 247-457-4 Spasmoctyl Otilonium bromide N,N-Diethyl-N-methy-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium Bromide N,N-Diethyl-N-methyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]ethanaminium bromide N,N-diethyl-2-[(4-{[2-(heptyloxy)benzoyl]amino}benzoyl)oxy]-N-methylethanaminium bromide
CAS	26095-59-0
EINECS	247-457-4
Chemical Formula	C29H43BrN2O4
Molecular Weight	563.57
inchi	InChI=1/C28H40N2O4.BrH/c1-5-8-9-10-13-21-33-26-15-12-11-14-25(26)27(31)29-24-18-16-23(17-19-24)28(32)34-22-20-30(4,6-2)7-3;/h11-12,14-19H,5-10,13,20-22H2,1-4H3;1H
Package	10 mM * 1 mL;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Otilonium bromide Otilonium bromide MedChemExpress (MCE) HY-B0499A 26095-59-0 Octylonium bromide Descriptions Otilonium bromide Otilonium bromide MedChemExpress (MCE) HY-B0499A 26095-59-0 Octylonium bromide SP63 99.69% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome. Otilonium bromide (10 nM-100 μM) inhibits acetylcholine-induced human colonic crypt calcium signals in a dose dependent manner with an IC50 of 880 nM[2]. Otilonium bromide (30 µM) inhibits Ca2+ uptake in bovine chromaffin cells[3]. \| \| \| \| \| \| \| \| \| \| [1]. Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12(10): p. 1003-10. [Content Brief]* [2]. Lindqvist S, et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 Dec 137(7):1134-42. [3]. Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117(3): p. 463-470. [Content Brief]
Last Update	2025-04-01 14:45:47

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