GR33343X MedChemExpress (MCE)

Product Name	Salmeterol
Synonyms	gr33343x SAMETEROL Salmeterol SALMETEROL SALMETEROL(SUBJECTTOPATENTFREE) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL (+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi Synonyms gr33343x SAMETEROL Salmeterol SALMETEROL SALMETEROL(SUBJECTTOPATENTFREE) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL (+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino] ethyl]-phenol 1,3-benzenedimethanol,4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl
CAS	89365-50-4
EINECS
Chemical Formula	C25H37NO4
Molecular Weight	415.57
inchi	InChI=1/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Salmeterol Salmeterol MedChemExpress (MCE) HY-14302 89365-50-4 GR33343X 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Salmeterol Salmeterol MedChemExpress (MCE) HY-14302 89365-50-4 GR33343X 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively. Salmeterol (0.001-25 μM) inhibits human T lymphocyte proliferation[2]. Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD)[3]. β2 adrenoceptor 9.6 (pEC50) β1 adrenoceptor 6.1 (pEC50) β3 adrenoceptor 5.9 (pEC50) \| \| \| \| \| \| \| \| \| \| [1]. Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15 19(20):6026-32. [Content Brief] [2]. Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec 110(6 Suppl):S282-90. [Content Brief] [3]. Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb 15(2):1538-1545. [Content Brief]
Last Update	2025-04-01 14:45:47

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