Aceclofenac MedChemExpress (MCE)

Product Name	Aceclofenac
Synonyms	Gerbin Falcol Airtal Preservex ACECLOFENAC Aceclofenac ACECLOFENAC-D2 Synonyms Gerbin Falcol Airtal Preservex ACECLOFENAC Aceclofenac ACECLOFENAC-D2 Glycolic Acid [o-(2,6-Dichloroanilino)phenyl]acetate Ester [({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid 2-(2-(2-(2,6-dichlorophenyl)aminophenyl)acetyl)oxyacetic acid 2-((2,6-dichlorophenyl)amino)-benzeneacetic aci carboxymethyl ester
CAS	89796-99-6
EINECS	641-844-5
Chemical Formula	C16H13Cl2NO4
Molecular Weight	354.18
inchi	InChI=1/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Aceclofenac Aceclofenac MedChemExpress (MCE) HY-B0634 89796-99-6 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Aceclofenac Aceclofenac MedChemExpress (MCE) HY-B0634 89796-99-6 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis. Aceclofenac (1-30 μM 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes[1]. Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test[1]. Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes[2]. Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg)[3]. Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg)[3]. COX-2 3 μM (IC50) COX-1 7.3 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Y Henrotin, et al. In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators. Inflamm Res. 2001 Aug 50(8):391-9. [Content Brief] [2]. E Maneiro, et al. Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes. J Rheumatol. 2001 Dec 28(12):2692-9. [Content Brief] [3]. E Maneiro, et al. Keumhan Noh, et al. Absolute bioavailability and metabolism of aceclofenac in rats. Arch Pharm Res. 2015 Jan 38(1):68-72. [Content Brief]
Last Update	2025-04-01 14:45:47

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