WAL801 MedChemExpress (MCE)

Product Name	Epinastine
Synonyms	WAL801 CS-1366 ELESTAT Epinastine EPINASTINE Apinastine Base EPINASTINE BASE Synonyms WAL801 CS-1366 ELESTAT Epinastine EPINASTINE Apinastine Base EPINASTINE BASE Epinastine base 3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine
CAS	80012-43-7
EINECS	616-785-3
Chemical Formula	C16H15N3
Molecular Weight	249.31
inchi	InChI=1/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
Package	10 mM * 1 mL;50 mg;100 mg;500 mg
Price	Email to quote
Descriptions	Epinastine Epinastine MedChemExpress (MCE) HY-B0640 80012-43-7 WAL801 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions Epinastine Epinastine MedChemExpress (MCE) HY-B0640 80012-43-7 WAL801 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action. Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain[2]. Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P[3]. Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases[4]. Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs[1]. H1 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Fugner, A., et al., In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung, 1988. 38(10): p. 1446-53. [Content Brief] [2]. Roeder, T., J. Degen, and M. Gewecke, Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. Eur J Pharmacol, 1998. 349(2-3): p. 171-7. [Content Brief] [3]. Kamei, C., et al., Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol, 1992. 14(1-2): p. 191-205. [Content Brief] [4]. Kohyama, T., et al., A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun, 1997. 230(1): p. 125-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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