MK-639 free base; L-735524 free base MedChemExpress (MCE)

Product Name	Indinavir
Synonyms	IDV MK-639 L-735524 Indinavir INDINAVIR Indinavir(MK-639 (1(1S,2R)5(S))-2,3,5-TRIDEOXY-N-(2,3-DIHYDRO-2HYDROXY-1H-INDEN-1-YI)- Synonyms IDV MK-639 L-735524 Indinavir INDINAVIR Indinavir(MK-639 (1(1S,2R)5(S))-2,3,5-TRIDEOXY-N-(2,3-DIHYDRO-2HYDROXY-1H-INDEN-1-YI)- Indinavir∫(1(1S,2R)5(S))-2,3,5-TRIDEOXY-N-(2,3-DIHYDRO-2HYDROXY-1H-INDEN-1-YI)- (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxyindan-1-yl]amino]-5-oxo-pentyl]-N-tert-butyl-4-(3-pyridylmethyl)piperazine-2-carboxamide [I(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3．Dihydro-2-hydrox-Lh-inden-1-y1)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide
CAS	150378-17-9
EINECS
Chemical Formula	C36H47N5O4
Molecular Weight	613.79
inchi	InChI=1/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Indinavir Indinavir MedChemExpress (MCE) HY-B0689 150378-17-9 MK-639 free base Descriptions Indinavir Indinavir MedChemExpress (MCE) HY-B0689 150378-17-9 MK-639 free base L-735524 free base 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor. Indinavir (0-50 μM 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1]. Indinavir (40 μM-40 nM 5 days) inhibits cell invasion and (40 μM-40 nM 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2]. Indinavir (70 mg/kg i.g. once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2]. HIV-1 MMP-2 \| \| \| \| \| \| \| \| \| \| [1]. Chavan S, et al. The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals. Blood. 2001 Jul 15 98(2):383-9. [Content Brief] [2]. Esposito V, et al. Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clin Cancer Res. 2006 Apr 15 12(8):2634-9. [Content Brief] [3]. Liu F, et al. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9 354(4):789-800. [Content Brief] [4]. Hall DC Jr, et al. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med Infect Dis. 2020 May-Jun 35:101646. [Content Brief]
Last Update	2025-04-01 14:45:47

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