CP-62993 dihydrate MedChemExpress (MCE)

Product Name	Azithromycin dihydrate
Synonyms	Azithromycin dihydrate;AZITHROMYCIN 2-HYDRATE;1-Oxa-6-azacyclopentadecan-15-one, 13-(2,6-dideoxy-3-C-methyl-3-O-methyl-.
CAS	117772-70-0
EINECS	641-134-5
Chemical Formula	C38H72N2O12·2H2O
Molecular Weight	785.02
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Package	10 mM * 1 mL;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Azithromycin hydrate Azithromycin hydrate MedChemExpress (MCE) HY-17506A 117772-70-0 CP-62993 dihydrate 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions Azithromycin hydrate Azithromycin hydrate MedChemExpress (MCE) HY-17506A 117772-70-0 CP-62993 dihydrate 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells[2]. Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice[1]. THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. Macrolide \| \| \| \| \| \| \| \| \| \| [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief] [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3 12(4):e0174853. [Content Brief]
Last Update	2025-04-01 14:45:47

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