HSR803 MedChemExpress (MCE)

Product Name	Itopride Hydrochloride
Synonyms	hsr803 ITOPRIDE HCL Itopride HCl ITOPRIDE HYDROCHLORIDE Itopride Hydrochloride N-(p-(2-(Dimethylamino)ethoxy)benzyl)veratramide Hydrochloride N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide Hydrochloride Synonyms hsr803 ITOPRIDE HCL Itopride HCl ITOPRIDE HYDROCHLORIDE Itopride Hydrochloride N-(p-(2-(Dimethylamino)ethoxy)benzyl)veratramide Hydrochloride N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide Hydrochloride n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohy n-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamidehydrochloride n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamidemonohydr n-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide hydrochloride n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohydrochloride
CAS	122892-31-3
EINECS	602-905-1
Chemical Formula	C20H27ClN2O4
Molecular Weight	394.89
inchi	InChI=1/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
Package	10 mM * 1 mL;100 mg;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Itopride hydrochloride Itopride hydrochloride MedChemExpress (MCE) HY-B0732 122892-31-3 HSR803 99.84% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Itopride hydrochloride Itopride hydrochloride MedChemExpress (MCE) HY-B0732 122892-31-3 HSR803 99.84% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD). Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3]. Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3]. Itopride hydrochloride (30 mg/kg p.o.) significantly accelerates gastric emptying compared with the vehicle group[4]. Itopride hydrochloride (30 mg/kg p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4]. D2 Receptor AChE \| \| \| \| \| \| \| \| \| \| [1]. Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug 99(2):401-8. [Content Brief] [2]. Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21 11(27):4210-4. [Content Brief] [3]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30 49(3):472-8. [Content Brief] [4]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct 31(10):1917-22. [Content Brief]
Last Update	2025-04-01 14:45:47

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