TubA MedChemExpress (MCE)

Product Name	Tubulysin A
Synonyms	TubA CS-1324 Tubulysin A Tubulysins A Tubulysin A,TubA (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci Synonyms TubA CS-1324 Tubulysin A Tubulysins A Tubulysin A,TubA (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
CAS	205304-86-5
EINECS
Chemical Formula	C43H65N5O10S
Molecular Weight	844.07
inchi
Package	1 mg
Price	Email to quote
Descriptions	Tubulysin A Tubulysin A MedChemExpress (MCE) HY-15995 205304-86-5 TubA 99.08% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions Tubulysin A Tubulysin A MedChemExpress (MCE) HY-15995 205304-86-5 TubA 99.08% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin. The IC50 values of Tubulysin A in the NCI-H1299 (lung), HT-29 (colon) and A2780 (ovary) cell lines are 3, 1 and 2 nmol/L, respectively[4]. The IC50 values of Tubulysin A against L929 (mouse fibroblast) and KB-V1 (human cervical cancer multidrug resistant cell line) cells were 0.07 and 1.4 ng/ml, respectively[1]. Tubulysin A (1 nM, 10 nM 24h) has an antiangiogenic effect in HUVEC cells with IC50 values of 2.07-2.97 nM[1]. Tubulysin A (5h) can inhibit cell migration in HUVEC cells with IC50 value of 2.26 nM[1]. Tubulysin A (72h) can inhibit cell growth in HUVEC cells with GI50 value of 0.34 nM[1]. Tubulysin A (0.04 mg/kg, 0.06 mg/kg Intraperitoneal (i.p.) once daily for 4 days) can inhibit the growth of tumor cells in mouse xenotransplantation model[1]. Traditional Cytotoxic Agents \| \| \| \| \| \| \| \| \| \| [1]. Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1 396(2):235-42. [Content Brief] [2]. Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep 53(9):879-85. [Content Brief] [3]. Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr 7(4):678-83. [Content Brief] [4]. Schluep T, et al. Polymeric tubulysin-peptide nanoparticles with potent antitumor activity. Clin Cancer Res. 2009 Jan 1 15(1):181-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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