GSK2141795 MedChemExpress (MCE)

Product Name	GSK2141795
Synonyms	CS-1304 UPROSERTIB Uprosertib GSK2141795 GSK 2141795C GSK-2141795,UPROSERTIB Uprosertib(GSK2141795) Synonyms CS-1304 UPROSERTIB Uprosertib GSK2141795 GSK 2141795C GSK-2141795,UPROSERTIB Uprosertib(GSK2141795) Uprosertib , GSK2141795C N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide
CAS	1047634-65-0
EINECS
Chemical Formula	C18H16Cl2F2N4O2
Molecular Weight	429.25
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Uprosertib Uprosertib MedChemExpress (MCE) HY-15965 1047634-65-0 GSK2141795 99.74% -20°C, stored under nitrogen In solvent : -80°C, 1 year Descriptions Uprosertib Uprosertib MedChemExpress (MCE) HY-15965 1047634-65-0 GSK2141795 99.74% -20°C, stored under nitrogen In solvent : -80°C, 1 year -20°C, 6 months (stored under nitrogen) Room temperature in continental US may vary elsewhere. Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. Uprosertib (GSK2141795) inhibits Akt1/2/3 with the Kd values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib (GSK2141795) in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding[1]. Akt3 38 nM (IC50) Akt1 180 nM (IC50) Akt2 328 nM (IC50) ROCK1 1570 nM (IC50) ROCK2 1850 nM (IC50) CDK7 2100 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2 12(8):3792-800. [Content Brief] [2]. Jacobsen K, et al. Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer. Nat Commun. 2017 Sep 4 8(1):410. [Content Brief]
Last Update	2025-04-01 14:45:47

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