Kobe2602 MedChemExpress (MCE)

Product Name	2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide
Synonyms	CS-1280 kobe2602 kobe-2602 KOBE-2602 kobe 2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide 2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide Synonyms CS-1280 kobe2602 kobe-2602 KOBE-2602 kobe 2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide 2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide kobe-2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide
CAS	454453-49-7
EINECS
Chemical Formula	C14H9F4N5O4S
Molecular Weight	419.31
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;250 mg
Price	Email to quote
Descriptions	Kobe2602 Kobe2602 MedChemExpress (MCE) HY-15717 454453-49-7 98.15% Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Kobe2602 Kobe2602 MedChemExpress (MCE) HY-15717 454453-49-7 98.15% Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Kobe2602 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity. Kobe2602 (2-20 μM 1 hour) exhibits Ras-Raf-binding inhibition in NIH 3T3 cells[1]. Kobe2602 has IC50 value of approximately 10 μM for the cellular Ras-Raf-binding inhibition[1]. Kobe2602 (20 μM) efficiently inhibits the phosphorylation of MEK and ERK, downstream kinases of Raf in NIH 3T3 cells transiently expressing H-RasG12V[1]. Kobe2602 inhibits Ras?GTP but not Ras?GDP[1]. Kobe2602 (20 μM) inhibits the anchorage-dependent proliferation of H-RasG12V-transformed cells[1]. Kobe2602 (80 mg/kg p.o. five consecutive days per week for 17 days) exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-RasG12V gene[1]. Ki: 149 μM (Ras-Raf interaction)[1] In Vitro Kobe2602 (2-20 μM 1 hour) exhibits Ras-Raf-binding inhibition in NIH 3T3 cells[1]. Kobe2602 has IC50 value of approximately 10 μM for the cellular Ras-Raf-binding inhibition[1]. Kobe2602 (20 μM) efficiently inhibits the phosphorylation of MEK and ERK, downstream kinases of Raf in NIH 3T3 cells transiently expressing H-RasG12V[1]. Kobe2602 inhibits Ras?GTP but not Ras?GDP[1]. Kobe2602 (20 μM) inhibits the anchorage-dependent proliferation of H-RasG12V-transformed cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Kobe2602 Related Antibodies Cell Proliferation Assay[1] Cell Line: H-rasG12V-transformed NIH 3T3 cells \| \| \| \| \| \| \| \| \| \| [1]. Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187, S8182/1-S8182/10. [Content Brief]
Supplier Website	https://www.medchemexpress.com/kobe2602.html
Last Update	2025-05-21 16:50:25

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