endo-IWR 1; IWR-1-endo MedChemExpress (MCE)

Product Name	IWR-1-endo
Synonyms	IWR1 IWR 1 IWR-1 ENDO-IWR 1 IWR-1-ENDO IWR-1-endo endo-IWR 1 Synonyms IWR1 IWR 1 IWR-1 ENDO-IWR 1 IWR-1-ENDO IWR-1-endo endo-IWR 1 [(3aR,4S,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-Methano-2H-isoindol-2-yl]-N-8-quinolinylbenzaMide Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel- rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo
CAS	1127442-82-3
EINECS
Chemical Formula	C25H19N3O3
Molecular Weight	409.44
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	IWR-1 IWR-1 MedChemExpress (MCE) HY-12238 1127442-82-3 endo-IWR 1 Descriptions IWR-1 IWR-1 MedChemExpress (MCE) HY-12238 1127442-82-3 endo-IWR 1 IWR-1-endo 99.49% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly[1]. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage[2]. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 μM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression[3]. IC50: 180 nM (Wnt) Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Lu J, et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15 19(14):3825-7. [Content Brief] [2]. Zhang X, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28 9(10):1108-20. [Content Brief] [3]. Gupta PS, et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17 9(6):e100201. [Content Brief]
Last Update	2025-04-01 14:45:47

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