XEN445 MedChemExpress (MCE)

Product Name	XEN445
Synonyms	XEN445 CS-1251 XEN 445 XEN-445 (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid Synonyms XEN445 CS-1251 XEN 445 XEN-445 (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445 XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
CAS	1515856-92-4
EINECS
Chemical Formula	C18H17F3N2O3
Molecular Weight	366.33
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	XEN445 XEN445 MedChemExpress (MCE) HY-12246 1515856-92-4 99.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions XEN445 XEN445 MedChemExpress (MCE) HY-12246 1515856-92-4 99.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. XEN445 is an endothelial lipase (EL) inhibitor with an IC50 of 0.237 uM. It has excellent ADME and PK activity and can increase the concentration of high-density lipoprotein cholesterol in mouse plasma. \| \| \| \| \| \| \| \| \| \| [1]. Sun S, et al. Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem. 2013 Dec 15 21(24):7724-34. [Content Brief]
Last Update	2025-04-01 14:45:47

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