BY1023; SKF96022 MedChemExpress (MCE)

Product Name	Pantoprazole
Synonyms	Pantoprazole PANTOPRAZOLE 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1h-benzimidazole 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzoimidazole Synonyms Pantoprazole PANTOPRAZOLE 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1h-benzimidazole 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzoimidazole 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-yridinyl)methyl]sulfinyl]-1h-benzimidazole 5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl }-1H-benzimidazole 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
CAS	102625-70-7
EINECS	600-331-6
Chemical Formula	C16H15F2N3O4S
Molecular Weight	383.37
inchi	InChI=1/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
Package	10 mM * 1 mL;100 mg;500 mg
Price	Email to quote
Descriptions	Pantoprazole Pantoprazole MedChemExpress (MCE) HY-17507 102625-70-7 BY1023 Descriptions Pantoprazole Pantoprazole MedChemExpress (MCE) HY-17507 102625-70-7 BY1023 SKF96022 99.94% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142). Pantoprazole (BY1023 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells[1]. Pantoprazole (BY10232) can block exosome release. Pantoprazole (BY10232) inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium[2] Pantoprazole (BY1023 200 mg/kg IP once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1]. Pantoprazole (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats[4]. proton pump Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Krupa J Patel, et al. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15 19(24):6766-76. [Content Brief] [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec 35(1):1322-1330. [Content Brief] [3]. W Beil, et al. Pantoprazole: a novel H+/K(+)-ATPase inhibitor with an improved pH stability. Eur J Pharmacol. 1992 Aug 6 218(2-3):265-71. [Content Brief] [4]. K Takeuchi, et al. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: a comparative study with omeprazole and lansoprazole. J Gastroenterol Hepatol. 1999 Mar 14(3):251-7. [Content Brief]
Last Update	2025-04-01 14:45:47

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