SKPin C1 MedChemExpress (MCE)

Product Name	Skp2 Inhibitor C1
Synonyms	CS-1230;MDK-1699;SKPin C1;Skp2-IN-C1;kp2 Inhibitor C1;Skp2 Inhibitor C1;Skp2 inhibitor C1 (SKPin C1);2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
CAS	432001-69-9
EINECS
Chemical Formula	C18H13BrN2O4S2
Molecular Weight	465.34
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Skp2 Inhibitor C1 Skp2 Inhibitor C1 MedChemExpress (MCE) HY-16661 432001-69-9 SKPin C1 98.21% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Skp2 Inhibitor C1 Skp2 Inhibitor C1 MedChemExpress (MCE) HY-16661 432001-69-9 SKPin C1 98.21% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Skp2 Inhibitor C1 (SKPin C1) is an S-phase kinase-related protein 2 (Skp2) inhibitor with an inhibitory effect on metastatic melanoma cells. Skp2 Inhibitor C1 slows the cell cycle, inhibits cell proliferation, and triggers apoptosis. Skp2 Inhibitor C1 (10-50 μM 12 hr) decreases the viability of THP-1, U266 and RPMI 8226 cells[1]. Skp2 Inhibitor C1 (25 μM) increases p27 protein levels in U266 and RPMI 8226 cells by inhibiting ubiquitination[1]. Skp2 Inhibitor C1 (25 μM) inhibits cell cycle of U266 and RPMI 8226 cells[1]. Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT)[2]. \| \| \| \| \| \| \| \| \| \| [1]. Yang Y, et al. Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis. Braz J Med Biol Res. 2019 52(5):e8412. [Content Brief] [2]. Li F, et al. Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. Behav Pharmacol. 2021 Feb 1 32(1):62-72. [Content Brief]
Last Update	2025-04-01 14:45:47

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