PST 2238 MedChemExpress (MCE)

Product Name	(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
Synonyms	PST2238 ROSTAFUROXIN Rostafuroxin Rostafuroxin PST2284 Rostafuroxin (PST-2238) (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Synonyms PST2238 ROSTAFUROXIN Rostafuroxin Rostafuroxin PST2284 Rostafuroxin (PST-2238) (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
CAS	156722-18-8
EINECS
Chemical Formula	C23H34O4
Molecular Weight	374.51
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Rostafuroxin Rostafuroxin MedChemExpress (MCE) HY-12283 156722-18-8 PST 2238 99.03% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Rostafuroxin Rostafuroxin MedChemExpress (MCE) HY-12283 156722-18-8 PST 2238 99.03% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity. Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na+,K+-ATPase phosphorylation and activation[3][4]. Rostafuroxin (0.125-128 μM for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC50=1.8 μM) and A549 cells (IC50=14.8 μM)[3]. Rostafuroxin displaced [3H]Ouabain from the dog kidney Na+,K+-ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10-4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors[1]. Rostafuroxin (PST 2238 1 mg/kg/day gavage for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation[4]. \| \| \| \| \| \| \| \| \| \| [1]. Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem. 1997 May 23 40(11):1561-4. [Content Brief] [2]. Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther. 1999 Mar 288(3):1074-83. [Content Brief] [3]. Matthias Lingemann, et al. The alpha-1 subunit of the Na⁺,K⁺-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PLoS Pathog. 2019 Aug 5 15(8):e1007963. [Content Brief] [4]. Camilla F Wenceslau, et al. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na⁺,K⁺-ATPase/cSRC pathway. J Hypertens. 2014 Mar 32(3):542-54. [Content Brief]
Last Update	2025-04-01 14:45:47

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