(S)-EX-527 MedChemExpress (MCE)

Product Name	EX527
Synonyms	EX527 CS-573 EX-527(S) EX-527(S-enantiomer) EX-527 (S-enantioMer) Selisistat S-enantiomer Selisistat S-enantiomer(EX-527 S-enantiomer) Synonyms EX527 CS-573 EX-527(S) EX-527(S-enantiomer) EX-527 (S-enantioMer) Selisistat S-enantiomer Selisistat S-enantiomer(EX-527 S-enantiomer) (1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527(S),(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide
CAS	848193-68-0
EINECS
Chemical Formula	C13H13ClN2O
Molecular Weight	248.71
inchi
Package	10 mM * 1 mL;1 mg;2 mg;5 mg;10 mg
Price	Email to quote
Descriptions	(S)-Selisistat (S)-Selisistat MedChemExpress (MCE) HY-15452A 848193-68-0 (S)-EX-527 99.39% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions (S)-Selisistat (S)-Selisistat MedChemExpress (MCE) HY-15452A 848193-68-0 (S)-EX-527 99.39% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM. (S)-Selisistat is an inhibitor of SIRT1 enzymatic activity (IC50, 98 nM), identified in a high-throughput screen using bacterially expressed human SIRT1. (S)-Selisistat inhibits SIRT1 in a concentration-dependent manner with an IC50 of 38 nM, in agreement with the activity on bacterially expressed SIRT1. (S)-Selisistat has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM) but does not inhibit class I/II HDAC activity at concentrations up to 100 μM[1]. (S)-Selisistat exerts an inhibitory effect on SIRT1 activity without affecting SIRT1 expression on both mRNA and protein levels[2]. (S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3]. SIRT1 98 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan 26(1):28-38. [Content Brief] [2]. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20 10(3):e0120849. [Content Brief] [3]. Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun 23(6):1209-17. [Content Brief] [4]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15 48(25):8045-54. [Content Brief]
Last Update	2025-04-01 14:45:47

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