YC-93 MedChemExpress (MCE)

Product Name	nicardipine hydrochloride
Synonyms	dagan loxen dafil lincil Barizin Vasonas Dacarel Synonyms dagan loxen dafil lincil Barizin Vasonas Dacarel nicardil rs-69216 perdipina bionicard Antagonyl Nicardipine HCl Naratriptan HCl Diphenidol hydrochloride nicardipine hydrochloride methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride
CAS	54527-84-3
EINECS	259-198-4
Chemical Formula	C26H30ClN3O6
Molecular Weight	515.99
inchi	InChI=1/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Nicardipine hydrochloride Nicardipine hydrochloride MedChemExpress (MCE) HY-12515A 54527-84-3 YC-93 99.73% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Nicardipine hydrochloride Nicardipine hydrochloride MedChemExpress (MCE) HY-12515A 54527-84-3 YC-93 99.73% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure. Nicardipine (0.1-10 μM 24-48 h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate[2]. Nicardipine (0.3-10 mg/kg p.o.) shows antihypertensive properties[3]. LD50s of Nicardipine are 643 mg/kg (oral) and 557 mg/kg (oral) 18.1 mg/kg (intravenous) 25.0 mg/kg (intravenous) 735 mg/kg (subcutaneous) and 683 mg/kg (subcutaneous) 171 mg/kg (intraperitoneally) and 155 mg/kg (intraperitoneally) for male and female Sprague-Dawley rats, respectively[3]. LD50s of Nicardipine are 187 mg/kg (oral) and 15.5 mg/kg (intravenous) for male Wistar rats, respectively[3]. LD50s of Nicardipine are 634 mg/kg (oral) and 650 mg/kg (oral) 20.7 mg/kg (intravenous) 19.9 mg/kg (intravenous) 540 mg/kg (subcutaneous) and 710 mg/kg (subcutaneous) 144 mg/kg (intraperitoneally) and 161 mg/kg (intraperitoneally) for male and female mice, respectively[3]. IC50: 1 μM (cardiac calcium channels)[1] In Vitro Nicardipine (0.1-10 μM 24-48 h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Nicardipine hydrochloride Related Antibodies Cell Viability Assay[2] Cell Line: VSMCs were isolated from New Zealand rabbit aortic preparations \| \| \| \| \| \| \| \| \| \| [1]. Charnet P, et al. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam Clin Pharmacol. 1987 1(6):413-31. [Content Brief] [2]. R Stamatiou, et al. The dihydropyridine calcium antagonist nicardipine reduces aortic smooth muscle cell viability, proliferation and migration. Cardiovascular Research, 2018 Apr,114(1):S43. [3]. Sherrin H. Baky. Nic ardipine Hydrochloride.
Supplier Website	https://www.medchemexpress.com/Nicardipine-Hydrochloride.html
Last Update	2025-05-21 16:50:25

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