FTI-277 MedChemExpress (MCE)

Product Name	FTI-277 (hydrochloride)
Synonyms	FTI 277 CS-1757 FTI 277 HCl FTI 277 HCL FTI 277 HYDROCHLORIDE FTI-277 (hydrochloride) FTI-277 TRIFLUOROACETATE SALT Synonyms FTI 277 CS-1757 FTI 277 HCl FTI 277 HCL FTI 277 HYDROCHLORIDE FTI-277 (hydrochloride) FTI-277 TRIFLUOROACETATE SALT 4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride (S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl
CAS	180977-34-8
EINECS	604-604-1
Chemical Formula	C22H30ClN3O3S2
Molecular Weight	484.075
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Package	10 mM * 1 mL;1 mg;2 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	FTI-277 hydrochloride FTI-277 hydrochloride MedChemExpress (MCE) HY-15872A 180977-34-8 98.29% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions FTI-277 hydrochloride FTI-277 hydrochloride MedChemExpress (MCE) HY-15872A 180977-34-8 98.29% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase) a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection. Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3]. FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2]. \| \| \| \| \| \| \| \| \| \| [1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct 152(4):404-11. [Content Brief] [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16 10(1):e0116633. [Content Brief] [3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug 34(8):815-26. [Content Brief] [4]. Bordier BB, et al. A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. J Virol. 2002 Oct 76(20):10465-72. [Content Brief]
Supplier Website	https://www.medchemexpress.com/FTI-277-hydrochloride.html
Last Update	2025-05-21 16:50:25

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