K-7174 MedChemExpress (MCE)

Product Name	K-7174
Synonyms	K7174;K-7174; K 7174;K-7174(FREE BASE);1H-1,4-Diazepine, hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-
CAS	191089-59-5
EINECS
Chemical Formula	C33H48N2O6
Molecular Weight	568.74
inchi
Package	5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	K-7174 K-7174 MedChemExpress (MCE) HY-12743 191089-59-5 98.02% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions K-7174 K-7174 MedChemExpress (MCE) HY-12743 191089-59-5 98.02% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer. K-7174 (10 μM 1 h) inhibits the adhesion by VCAM-1 and its ligand[1]. K-7174 (1-30 μM 1 h) dose-dependently suppresses the VCAM-1 expression with an IC50 value of 14 μM[1]. K-7174 (1-30 μM 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC50 value of 9 μM[1]. K-7174 (10-20 μM 24 h) dose-dependently rescues Epo production by Hep3B cells[2]. K-7174 (2.5-30 μM 24 h) inhibits the binding activity of GATA[2]. K-7174 (0-25 μM 72 h) inhibits MM cells growth and induces cell apoptosis[3]. K-7174 (30 mg/kg i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α[2]. K-7174 (75 mg/kg i.p. once daily for 14 days) inhibits the tumor growth in vivo[3]. K-7174 (50 mg/kg p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection[3]. \| \| \| \| \| \| \| \| \| \| [1]. Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7 272(2):370-4. [Content Brief] [2]. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep 17(12):1742-4. [Content Brief] [3]. Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30 288(35):25593-602. [Content Brief]
Last Update	2025-04-01 14:45:47

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