MK-3102 MedChemExpress (MCE)

Product Name	Omarigliptin
Synonyms	MK-3012 MK-3102 Omarigliptin OMarigliptin OMarigliptin (MK-3102) (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine Synonyms MK-3012 MK-3102 Omarigliptin OMarigliptin OMarigliptin (MK-3102) (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (2S,3R,5S)-2-(2,5-Difluorophenyl)-5-[2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-aMine (MK-3102 enantioMer) 2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine MK3102
CAS	1226781-44-7
EINECS	682-558-0
Chemical Formula	C17H20F2N4O3S
Molecular Weight	398.43
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Package	10 mM * 1 mL;1 mg;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Omarigliptin Omarigliptin MedChemExpress (MCE) HY-15981 1226781-44-7 MK-3102 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Omarigliptin Omarigliptin MedChemExpress (MCE) HY-15981 1226781-44-7 MK-3102 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Omarigliptin (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. Omarigliptin shows anti-parkinsonian activity. Omarigliptin has the neuroprotective effect to improve diabetes-associated cognitive dysfunction. Omarigliptin (5 mg/kg p.o.) enhances the intestinal glucagon like peptide-1 and crosses BBB in rats[1]. Omarigliptin (2.5, 5 mg/kg p.o. once a week for 8 weeks) shows anti-diabetic activity in STZ-induced diabetic mice[2]. Omarigliptin (5 mg/kg p.o. daily for 28 days) shows anti-parkinsonian activity in rats[3]. DPP-4 \| \| \| \| \| \| \| \| \| \| [1]. Ayoub BM, et al. Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent. Sci Rep. 2018 Jun 12 8(1):8959. [Content Brief] [2]. Li X, et al. Omarigliptin alleviates cognitive dysfunction in Streptozotocin-induced diabetic mouse. Bioengineered. 2022 Apr 13(4):9387-9396. [Content Brief] [3]. Ayoub BM, et al. Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A2A Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS. Molecules. 2021 Feb 8 26(4):889. [Content Brief]
Last Update	2025-04-01 14:45:47

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