SW033291 MedChemExpress (MCE)

Product Name	SW033291
Synonyms	CS-1608 SW033291 SW033291(SW-033291) 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-amine Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)- Synonyms CS-1608 SW033291 SW033291(SW-033291) 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-amine Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)- 4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2- dihydropyridine-3-carbonitrile 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine
CAS	459147-39-8
EINECS
Chemical Formula	C21H20N2OS3
Molecular Weight	412.59
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	SW033291 SW033291 MedChemExpress (MCE) HY-16968 459147-39-8 99.68% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions SW033291 SW033291 MedChemExpress (MCE) HY-16968 459147-39-8 99.68% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration. Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC50 50 at approximately 75 nM[1]. SW033291 (10 mg/kg intraperitoneal injection twice daily for 3 days C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells[1]. Ki: 0.1 nM (15-PGDH)[1] In Vitro Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC50 50 at approximately 75 nM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SW033291 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Zhang Y, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 12 348(6240):aaa2340. [Content Brief]
Last Update	2025-04-01 14:45:47

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