MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride MedChemExpress (MCE)

Product Name	Fexofenadine Hydrochloride
Synonyms	Allegra Telfast MDL 16455A Telfast BD Fexofendine Hcl Fexofenadine HCl FEXOFENADINE-D10 HCL Synonyms Allegra Telfast MDL 16455A Telfast BD Fexofendine Hcl Fexofenadine HCl FEXOFENADINE-D10 HCL Fexofenadine hydrochloride Fexofenadine Hydrochloride terfenidine carboxylate hydrochloride CARBOXYTERFENADINE,TERFENADINECARBOXYLATE α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride 2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride 2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE
CAS	153439-40-8;138452-21-8
EINECS	604-906-2
Chemical Formula	C32H40ClNO4
Molecular Weight	538.13
inchi	InChI=1/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27 /h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) 1H/p-1
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Fexofenadine hydrochloride Fexofenadine hydrochloride MedChemExpress (MCE) HY-B0801A 153439-40-8 MDL-16455 hydrochloride Descriptions Fexofenadine hydrochloride Fexofenadine hydrochloride MedChemExpress (MCE) HY-B0801A 153439-40-8 MDL-16455 hydrochloride Terfenadine carboxylate hydrochloride 99.86% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research. Fexofenadine (1-100 μM 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2]. Fexofenadine (1-100 μM 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2]. Fexofenadine hydrochloride (oral administration 5-20 mg/kg once daily 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1]. H1 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar 4(3):367-75. [Content Brief]* [2]. Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov 6(6):567-72. [Content Brief] [3]. Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3 8(5):1677-86. [Content Brief]
Last Update	2025-04-01 14:45:47

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