Thioridazine MedChemExpress (MCE)

Product Name	thioridazine hydrochloride
Synonyms	usafsz-3 USAF SZ-B Novoridazine ThioridazinHCl melleril(tablet) THIORIDAZINE HCL LABOTEST-BB LT00451961 Synonyms usafsz-3 USAF SZ-B Novoridazine ThioridazinHCl melleril(tablet) THIORIDAZINE HCL LABOTEST-BB LT00451961 Thioridazinhydrochlorid Thioridazine chloridate thioridazine hydrochloride 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-10h-phenothiazinmono 2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine Hydrochloride 10-[2-(1-METHYL-2-PIPERIDYL)-ETHYL]-2-[METHYLTHIOL]-PHENOTHIAZINE HYDROCHLORIDE 10-[2-(1-METHYL-2-PIPERIDYL)ETHYL]-2-(METHYLTHIO)-10H-PHENOTHIAZINE HYDROCHLORIDE 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine Hydrochloride 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (9CI) 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-phenothiazinmonohydrochl 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylthiophenothiazinehydrochloride 2-methylmercapto-10-(2-(n-methyl-2-piperidyl)ethyl)phenothiazinehydrochlorid mellarilhydrochloride melleril(tablet) usafsz-3 ThioridazinHCl Thioridazinhydrochlorid 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine Hydrochloride 2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine Hydrochloride Orsanil Ridazin Stalleril 10H-Phenothiazine, 10-2-(1-methyl-2-piperidinyl)ethyl-2-(methylthio)-, monohydrochloride THIORIDAZINEHYDROCHLORIDE,USP 10-[3-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine hydrochloride
CAS	130-61-0
EINECS	204-992-8
Chemical Formula	C21H27ClN2S2
Molecular Weight	407.04
inchi	InChI=1/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
Package	10 mM * 1 mL;10 mM * 1 mL;100 mg;100 mg;500 mg;500 mg
Price	Email to quote
Descriptions	Thioridazine hydrochloride Thioridazine hydrochloride MedChemExpress (MCE) HY-B0965 130-61-0 99.96% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Thioridazine hydrochloride Thioridazine hydrochloride MedChemExpress (MCE) HY-B0965 130-61-0 99.96% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs). Thioridazine (0.01-100 μM 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner[2].Thioridazine (15 μM 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells[4].Thioridazine (1-15 μM 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway[2].Thioridazine (15 μM 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells [4].Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii[3]. Thioridazine (25 mg/kg i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors[5]. Thioridazine (1.0-5.0 mg/kg s.c.) reduces oral behavior and selectively blocks repetitive head bobbing[1]. serotonin \| \| \| \| \| \| \| \| \| \| [1]. Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov 31(3):519-22. [Content Brief] [2]. Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May 31(5):2107-14. [Content Brief] [3]. Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22. [Content Brief] [4]. Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep 17(9):989-97. [Content Brief] [5]. Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23 13(9):2045. [Content Brief]
Last Update	2025-04-01 14:45:47

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