Trimetazidine MedChemExpress (MCE)

Product Name	Trimetazidine HCL
Synonyms	Takkmint Vastarel F Yoshimilon Youmetazine Trimetazidine HCL Trimetazidine 2HCl Trimetazidine 3HCl Synonyms Takkmint Vastarel F Yoshimilon Youmetazine Trimetazidine HCL Trimetazidine 2HCl Trimetazidine 3HCl Trimetazidine Dihydrochloride 1-(2,3,4-trimethoxybenzyl)piperazine 1-(2,3,4-trimethoxybenzyl)piperazinediium 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride 1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE 1-[(2,3,4-Trimethoxy-phenyl)methyl]piperazine Dihydrochloride 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride,Trimetazidine dihydrochloride
CAS	13171-25-0
EINECS	236-117-0
Chemical Formula	C14H24Cl2N2O3
Molecular Weight	339.26
inchi	InChI=1/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3/p+2
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Trimetazidine dihydrochloride Trimetazidine dihydrochloride MedChemExpress (MCE) HY-B0968 13171-25-0 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Trimetazidine dihydrochloride Trimetazidine dihydrochloride MedChemExpress (MCE) HY-B0968 13171-25-0 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor. Trimetazidine (1 μM-100 μM 24 hours HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner[1]. Trimetazidine (5-20 mg/kg oral administration 1 hour Swiss albino male mice) in 10 mg/kg and 20 mg/kg doses significantly raises the seizure-threshold current in the increasing current electroshock seizure (ICES) test in the mice[5]. IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2] β-oxidation[2] Autophagy[3] 3-hydroxyacyl-CoA dehydrogenase (HADHA)[4] In Vitro Trimetazidine (1 μM-100 μM 24 hours HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Trimetazidine dihydrochloride Related Antibodies Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) \| \| \| \| \| \| \| \| \| \| [1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun 74(9):971-80. [Content Brief] [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17 86(5):580-8. [Content Brief] [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov 3(11):1236-47. [Content Brief] [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun 19(5):300-2. [Content Brief]
Last Update	2025-04-01 14:45:47

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