SB-265805S; LB-20304a MedChemExpress (MCE)

Product Name	Gemifioxacin mesylate
Synonyms	CS-775 LB-20304a SB-265805S LB-20304 Mesilate Gemifioxacin mesylate GEMIFIOXACIN MESYLATE (Z)-Gemifloxacin Mesilate Synonyms CS-775 LB-20304a SB-265805S LB-20304 Mesilate Gemifioxacin mesylate GEMIFIOXACIN MESYLATE (Z)-Gemifloxacin Mesilate (Z)-GEMIFLOXACIN MESILATE 7-(3-aminomethyl)-4-methoxyimino-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid mesylate 7-(3-Aminomethyl)-4-methoxyimino-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid mesylate
CAS	210353-53-0
EINECS	1312995-182-4
Chemical Formula	C19H24FN5O7S
Molecular Weight	485.49
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Gemifloxacin mesylate Gemifloxacin mesylate MedChemExpress (MCE) HY-B1050 210353-53-0 SB-265805S Descriptions Gemifloxacin mesylate Gemifloxacin mesylate MedChemExpress (MCE) HY-B1050 210353-53-0 SB-265805S LB-20304a 99.76% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Gemifloxacin mesylate (SB-265805S LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections. Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL[2]. Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL[2]. Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration[1]. Pharmacokinetic Parameters of Gemifloxacin in Sprague-Dawley rats and dogs[1]. Species Administration AUC0-24 (μg/mL·h) Half-life (h) Cmax (μg/mL) Tmax (h) F (%) Rat p.o. 20 mg/kg 8.50 2.33 2.44 0.33 95.3 Dog p.o. 4 mg/kg 7.55 5.12 1.34 1.13 71 Quinolone \| \| \| \| \| \| \| \| \| \| [1]. Hong CY. Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation. Farmaco. 2001 Jan-Feb 56(1-2):41-4. [Content Brief]* [2]. Allen A, Kim I, et al. Multiple-dose pharmacokinetics and tolerability of gemifloxacin administered orally to healthy volunteers. Antimicrob Agents Chemother. 2001 Feb 45(2):540-5. [Content Brief] [3]. Erdem M, et al. Ingestion of the anti-bacterial agent, gemifloxacin mesylate, leads to increased gst activity and peroxidation products in hemolymph of Galleria mellonella l. (lepidoptera: pyralidae). Arch Insect Biochem Physiol. 2016 Dec 93(4):202-209. [Content Brief]
Last Update	2025-04-01 14:45:47

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