CL-82204 MedChemExpress (MCE)

Product Name	Lederfen
Synonyms	cl82204 FENBUFEN Fenbufen Lederfen 4-biphenyl-4-yl-4-oxobutanoate 4-(4-BIPHENYL)-4-OXOBUTYRIC ACID 3-(4-PHENYLBENZOYL)PROPIONIC ACID Synonyms cl82204 FENBUFEN Fenbufen Lederfen 4-biphenyl-4-yl-4-oxobutanoate 4-(4-BIPHENYL)-4-OXOBUTYRIC ACID 3-(4-PHENYLBENZOYL)PROPIONIC ACID 4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID 4-(biphenyl-4-yl)-4-oxobutanoic acid diphenyl-4-gamma-oxo-gamma-butyricacid GAMMA-OXO(1,1'-BIPHENYL)-BUTANOIC ACID 3-(4-Biphenylylcarbonyl) propionic acid GAMMA-OXO-[1,1'-BIPHENYL]-4-BUTANOIC ACID
CAS	36330-85-5
EINECS	252-979-0
Chemical Formula	C16H14O3
Molecular Weight	254.29
inchi	InChI=1/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)/p-1
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Fenbufen Fenbufen MedChemExpress (MCE) HY-B1138 36330-85-5 CL-82204 99.33% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Fenbufen Fenbufen MedChemExpress (MCE) HY-B1138 36330-85-5 CL-82204 99.33% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor. Fenbufen (100-500 μM) improves the viability of apoptotic THP-1 cells treated with 25 μM Nigericin (HY-127019)[5]. Fenbufenmay (1200 mg/kg feed) does not cause gastric ulceration whilst inducing a near maximal inhibition of prostaglandin release in rats[6]. Fenbufenmay (1200 mg/kg p.o. diet for 10 days) blocks the hypertrophy of the heart but not that of the skeletal muscles[6]. COX-1 3.9 μM (IC50) COX-2 8.1 μM (IC50) Caspase-1 4.4 μM (IC50) Caspase-3 1.2 μM (IC50) Caspase-4 0.57 μM (IC50) Caspase-5 0.87 μM (IC50) Caspase-9 0.76 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. A E Sloboda, et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung. 1980 30(4A):716-21. [Content Brief] [2]. R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr 66(4):466-76. [Content Brief] [3]. A E Sloboda, et al. The pharmacology of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec 1(4):415-38. [Content Brief] [4]. Asif Husain, et al. Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep 44(9):3798-804. [Content Brief] [5]. Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16 24(3):281-292. [Content Brief] [6]. R M Palmer, et al. Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. Br J Pharmacol. 1990 Dec 101(4):835-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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