Sulfaphenazole MedChemExpress (MCE)

Product Name	SULFAPHENAZOLE
Synonyms	Orisul Orisulf Paidazolo SULFAPHENAZOLE LABOTEST-BB LT00772280 N1-(1-Phenylpyrazol-5-yl)sulfanilamide n'-(1-phenylpyrazol-5-yl)sulfanilamide Synonyms Orisul Orisulf Paidazolo SULFAPHENAZOLE LABOTEST-BB LT00772280 N1-(1-Phenylpyrazol-5-yl)sulfanilamide n'-(1-phenylpyrazol-5-yl)sulfanilamide n(sup1)-(1-phenylpyrazol-5-yl)sulfanilamide 4-AMINO-N-(1-PHENYL-1H-PYRAZOL-5-YL)BENZENESULFONAMIDE
CAS	526-08-9
EINECS	208-384-3
Chemical Formula	C15H14N4O2S
Molecular Weight	314.36
inchi
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Sulfaphenazole Sulfaphenazole MedChemExpress (MCE) HY-B1218 526-08-9 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Sulfaphenazole Sulfaphenazole MedChemExpress (MCE) HY-B1218 526-08-9 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion. Sulfaphenazole (10 μM for 1 h) causes the numbers of light-induced apoptotic and necrotic cells decreased by 33 and 44%, respectively[1]. Sulfaphenazole (5.13 mg/kg intraperitoneal injections daily for 8 weeks) restores endothelium-mediated relaxation in diabetic mice[2]. CYP2C9 \| \| \| \| \| \| \| \| \| \| [1]. Qing Chang, et al. Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. J Biol Chem. 2014 Mar 21 289(12):8337-52. [Content Brief] [2]. Shahrzad Elmi, et al. Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice. Vascul Pharmacol. 2008 Jan 48(1):1-8. [Content Brief] [3]. Christopher T Turner, et al. Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion. Sci Rep. 2022 Jul 23 12(1):12622. [Content Brief]
Last Update	2025-04-01 14:45:47

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