ACT-129968; KYTH-105 MedChemExpress (MCE)

Product Name	Seripiprant
Synonyms	KYTH105 KYTH 105 ACT129968 KYTH-105 ACT129968 ACT 129968 Setipiprant Synonyms KYTH105 KYTH 105 ACT129968 KYTH-105 ACT129968 ACT 129968 Setipiprant Seripiprant SETIPIPRANT ACT-129968 (Setipiprant) 2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid 2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid 8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid
CAS	866460-33-5
EINECS
Chemical Formula	C24H19FN2O3
Molecular Weight	402.42
inchi
Package	10 mM * 1 mL;10 mM * 1 mL;5 mg;5 mg;10 mg;10 mg;25 mg;25 mg;50 mg;50 mg
Price	Email to quote
Descriptions	Setipiprant Setipiprant MedChemExpress (MCE) HY-16635 866460-33-5 ACT-129968 Descriptions Setipiprant Setipiprant MedChemExpress (MCE) HY-16635 866460-33-5 ACT-129968 KYTH-105 98.23% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis. Setipiprant (0-10 μM 90 min) interacts with hCRTH2 receptor in the absence and presence of Human Serum Albumin (HSA) in the assay buffer with IC50 values of 6 and 340 nM, respectively[1]. Setipiprant (0-10 μM 5-20 min) inhibits hCRTH2 receptor based intracellular calcium liberation, intracellular cAMP and shape change of human eosinophils with IC50 values of 30, 80 and 235 nM, respectively[1]. Setipiprant (0-10 μM) inhibits prostanoid receptors hDP1, hEP2 and hEP4 with IC50 values of 1290, 2600 and ＞10000 nM, respectively[1]. 1.19 Pharmacokinetic Properties of Setipiprant in Rats and Dogs[1]. AUC0-last (ng•h/mL) CL (mL/min/kg) T1/2 (hr) F (%) RatsIV 2 mg/kg 58500 1.3 6 44 DogsPO 10 mg/kg 91100 55 hCRTH2 6 nM (IC50) hDP1 1290 nM (IC50) EP2 2600 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Heinz Fretz, et al. Identification of 2 (2-(1-Naphthoyl)-8-fluoro-3,4-dihydro 1H pyrido[4,3 b]indol-5(2H) yl)acetic Acid (Setipiprant/ACT 129968), a Potent, Selective, and Orally Bioavailable Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2) Antagonis. 2013.
Supplier Website	https://www.medchemexpress.com/Setipiprant.html
Last Update	2025-05-21 16:50:25

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